Pityriasis rosea (PR) is a self-limited cutaneous eruption that typically presents with the onset of a pink to salmon-colored herald patch on the trunk or proximal extremities followed by an acute dissemination of multiple oval scaly patches and plaques along skin cleavage lines [ 1 ]. While the etiology remains unclear, the current literature See letter "Reply to “the significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea‐like eruptions following COVID ‐19 vaccinations” by Ciccarese G. et al." in Dermatol Ther, volume 35, e15602. Kaj je pityriasis rosea? Je kožni izpuščaj, ki ponavadi traja 6 – 8 tednov. Je rožnate barve in se blago lušči. Kaj povzroča Pityriasis roseo? Etiologija ni pojasnena, morda je vzrok infektivni (virusi), saj se pogosto pojavlja v zagonih in v skupnostih (šole, vrtci, v družinah, naseljih), pogosteje se pojavlja pozimi. Persistent pityriasis rosea has been linked with and attributed to persistent reactivation of HHV-6 and/or HHV-7 with higher viral loads than in typical pityriasis rosea in a study of 12 patients. [ 42] In addition to the conditions listed in the differential diagnosis, other problems to be considered include the following: Primary HIV infection. Pityriasis rosea je běžná vyrážka, která obvykle postihuje lidi ve věku 18–35 let a zasahuje tělo, ale ne obličej. Pityriasis rosea obvykle začíná jednou větší červenou skvrnou na hrudníku nebo zádech, na jejímž místě se nejdříve za dva dny objeví menší rozsáhlá vyrážka. . Prečo je pityriasis rosea nebezpečná? Pityriasis rosea nie je život ohrozujúca, ale môže byť nebezpečná vo forme ekzému, dermatitídy a psoriázy. Pri rozškriabaní výražky sa do rany môže dostať infekcia a spôsobiť tak hnisavý zápal kože. Medzi komplikácie pityriasis rosey patrí aj folikulitída a streptokoková infekcia. The rash can be itchy. Pityriasis (pit-ih-RIE-uh-sis) rosea can happen at any age but is most common between the ages of 10 and 35. It tends to go away on its own within 10 weeks. Treatment may help relieve the symptoms. The rash persists for several weeks and heals without scarring. Alvin Friedman-Kien, MD, walked through the doorway into the exam room, looked at me and immediately said, “Oh, you have pityriasis rosea.” He called in a bunch of residents so he could show them my rash and teach them about the condition, which often has a large patch called the “mother patch” (or herald patch), as well as smaller Geographic tonguelike presentation in a child with pityriasis rosea: case report and review of oral manifestations of pityriasis rosea. Pediatr Dermatol. 2018;35:E124-E127. doi:10.1111/pde.13417 Sinha S, Sardana K, Garg V. Coexistence of two atypical variants of pityriasis rosea: a case report and review of literature. Summary. Pityriasis rosea is a common, benign, and self-limiting skin condition that primarily affects young adults. It is characterized by a rash that typically presents as a single, large, scaly, pink or red patch called the "herald patch" on the trunk, followed by the appearance of smaller, similar-appearing patches on the trunk, arms, and

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